USS Nicholas may refer to the following ships of the United States Navy: USS Nicholas was a Clemson-class destroyer, launched in 1919 and one of seven destroyers lost in the Honda Point Disaster on 8 September 1923 USS Nicholas was a Fletcher-class destroyer, launched in 1942 and struck in 1970 USS Nicholas is an Oliver Hazard Perry-class frigate, launched in 1983 and decommissioned in 2014 Wikipedia